Description

Thymidine 3'-Diphosphoric Acid CAS NO 978-33-6 is a high-purity nucleotide derivative essential for biochemical research and pharmaceutical development. This compound serves as a critical building block and substrate in enzymatic studies, particularly those involving DNA synthesis and repair pathways. It is primarily utilized by research institutions, diagnostic kit manufacturers, and biotechnology companies focused on molecular biology and nucleotide chemistry.

Application

• Enzymatic Substrate: Used as a specific substrate for enzymes like thymidylate kinase and other nucleotide kinases in kinetic and mechanistic studies.
• Biochemical Research: A key reagent in the study of DNA replication, repair mechanisms, and nucleotide metabolism pathways.
• Diagnostic Reagent Manufacturing: Incorporated into enzymatic assay kits for clinical diagnostics and life science research.
• Pharmaceutical Intermediate: Serves as a precursor in the synthesis of novel nucleoside-based antiviral or anticancer prodrugs.
• Metabolic Pathway Analysis: Employed in tracer studies and metabolic flux analysis using isotopic labeling (e.g., ³²P, ¹⁴C).
• Cell Culture & Media Supplement: Used in specialized cell culture media formulations for studying nucleotide requirements.

Basic Information

Product Name	Thymidine 3'-Diphosphoric Acid
CAS No.	978-33-6
Molecular Formula	C₁₀H₁₇N₂O₁₁P₂
Molecular Weight	418.20 g/mol
Synonyms	3'-dTDP; Thymidine 3'-pyrophosphate; 3'-Thymidylic acid diphosphate; dTDP; Thymidine-3'-diphosphate; 2'-Deoxythymidine 3'-(trihydrogen diphosphate); 3'-TDP; 5-Methyl-2'-deoxyuridine 3'-diphosphate
EINECS	Contact for details

Quality Control

Our Thymidine 3'-Diphosphoric Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality system is designed to meet the rigorous standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.