Description

O6-Methyl-2'-Deoxyguanosine is a modified nucleoside of significant interest in biochemical and pharmaceutical research. This compound serves as a critical reference standard and tool for studying DNA alkylation damage, repair mechanisms, and mutagenesis. It is essential for researchers and quality control laboratories in the fields of oncology, toxicology, and molecular biology who require high-purity biochemicals for accurate analytical work.

Application

• Biochemical Research Standard: Used as a primary analytical standard for the quantification of O6-methylguanine lesions in DNA, a key biomarker of exposure to alkylating agents.
• DNA Damage & Repair Studies: Essential for in vitro and in vivo studies investigating the mechanisms of DNA repair pathways, such as those involving MGMT (O6-methylguanine-DNA methyltransferase).
• Oncology & Cancer Research: Employed in research focused on the mutagenic and carcinogenic effects of environmental and therapeutic alkylating agents.
• Toxicology & Biomarker Analysis: Acts as a calibrant in mass spectrometry and HPLC-based methods for detecting DNA adducts in biological samples for exposure assessment.
• Pharmaceutical Development: Utilized in the development and validation of assays for novel chemotherapeutic agents that target or are affected by DNA alkylation.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes studying genotoxicity, epigenetics, and chemical carcinogenesis.

Basic Information

Product Name	O6-Methyl-2'-Deoxyguanosine
CAS No.	964-21-6
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	O6-Methyl-2'-deoxyguanosine; O6-Methyl-deoxyguanosine; 2'-Deoxy-O6-methylguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methoxyamino)-1H-purin-2-one; O6-Me-dG; 6-Methoxyamino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine; O6-Methylguanine deoxyriboside
EINECS	Contact for details

Quality Control

Our O6-Methyl-2'-Deoxyguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and quality standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.