Description

3-Methylthymidine is a modified nucleoside derivative of thymidine, featuring a methyl group at the 3-position of the pyrimidine ring. This structural modification makes it a valuable intermediate in the synthesis of novel oligonucleotides and for probing nucleic acid structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced nucleic acid chemistry and drug discovery. The compound, with CAS number 958-74-7, is essential for developing targeted molecular probes and therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of modified antisense oligonucleotides and other therapeutic nucleic acids.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand DNA/RNA metabolism and repair mechanisms.
• Probe Development: Incorporated into oligonucleotide probes to study DNA-protein interactions and for diagnostic assay development.
• Medicinal Chemistry: Serves as a core scaffold for the development of novel nucleoside analog drugs targeting viral infections or cancer.
• Academic Research: Fundamental tool in university and institutional labs for studying the effects of base methylation on nucleic acid stability and hybridization.

Basic Information

Product Name	3-Methylthymidine
CAS No.	958-74-7
Molecular Formula	C11H16N2O5
Molecular Weight	256.26 g/mol
Synonyms	3-Methylthymidine; 1-(2-Deoxy-β-D-ribofuranosyl)-3-methyluracil; 3-Methyl-2'-deoxythymidine; 3-Methyl-1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil; 3-Methyldeoxythymidine; Thymidine, 3-methyl-; 2'-Deoxy-3-methyluridine
EINECS	Contact for details

Quality Control

Our 3-Methylthymidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.