Description

5-Bromouridine is a halogenated nucleoside analog that serves as a critical building block in nucleic acid research and pharmaceutical development. Its primary value lies in its ability to be incorporated into oligonucleotides, enabling the study of RNA structure, function, and interactions. This compound is essential for researchers and manufacturers in the fields of biochemistry, molecular biology, and medicinal chemistry, particularly for developing probes and potential therapeutic agents.

Application

• Oligonucleotide Synthesis: Used as a modified nucleoside precursor for incorporating bromine atoms into DNA or RNA strands.
• Biochemical Research: Serves as a tool for studying RNA structure, folding, and protein-RNA interactions via halogen bonding or as a heavy atom derivative.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the development of nucleoside-based antiviral or anticancer prodrugs.
• X-ray Crystallography: Utilized as a heavy-atom label to facilitate phase determination in the structural analysis of nucleic acids.
• Cross-linking Studies: Employed in photo-activatable cross-linking experiments to investigate nucleic acid conformations and complexes.
• Antisense Technology: Potential use in the synthesis of modified antisense oligonucleotides for therapeutic and diagnostic applications.

Basic Information

Product Name	5-Bromouridine
CAS No.	957-75-5
Molecular Formula	C9H11BrN2O6
Molecular Weight	323.10 g/mol
Synonyms	5-BrUrd; 5-Bromo-1-β-D-ribofuranosyluracil; 5-Bromouridine, 1-β-D-Ribofuranosyl-5-bromouracil; Bromouridine; 5-Bromo-UR; 5-Br-Uridine; β-5-Bromouridine
EINECS	213-500-1

Quality Control

Our 5-Bromouridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.