Description

2,4,6-Trimethylbenzoyl Chloride is a versatile and highly reactive acyl chloride derivative of mesitylene. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the 2,4,6-trimethylbenzoyl moiety into target molecules. It is primarily sought after by research and development chemists, as well as process engineers, in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of advanced intermediates, photoinitiators, and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly in amide and ester bond formation.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the mesityl group imparts specific biological activity and stability.
• Photoinitiator Manufacturing: Acts as a precursor for high-performance photoinitiators used in UV-curable inks, coatings, and adhesives.
• Polymer Chemistry: Employed in the modification of polymers and the synthesis of monomers to alter material properties like solubility and thermal stability.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and organometallic catalysts for asymmetric synthesis and cross-coupling reactions.
• Organic Synthesis Research: A valuable tool in academic and industrial R&D for constructing complex molecular architectures, including natural product analogs.

Basic Information

Item	Detail
Product Name	2,4,6-Trimethylbenzoyl Chloride
CAS No.	938-18-1
Molecular Formula	C10H11ClO
Molecular Weight	182.65 g/mol
Synonyms	Mesityloyl Chloride; 2,4,6-Trimethylbenzoyl chloride; Mesitoyl Chloride; TMB-Cl; 2,4,6-Trimethylbenzenecarbonyl chloride; NSC 403780; AI3-15311
EINECS	213-342-5

Quality Control

Our 2,4,6-Trimethylbenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (IR, NMR), to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.