Description

p-Tolyl Chloroformate is a versatile and highly reactive organic intermediate primarily used as a key building block in the synthesis of more complex molecules. Its value lies in its ability to act as a protecting group for alcohols and amines, as well as a reagent for introducing the p-tolyloxycarbonyl moiety. This compound is essential for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for research, process development, and commercial-scale production.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for carbamate and carbonate prodrug formation.
• Peptide Synthesis: Used as a coupling agent and for introducing protecting groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Serves as a key intermediate in the manufacture of certain herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Employed in the production of specialty polymers, including polycarbonates and polyurethanes, and as a surface modifying agent.
• Chemical Research & Development: A valuable tool for organic chemists in academia and industry for constructing complex molecular architectures.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of certain advanced colorants and photographic chemicals.

Basic Information

Product Name	p-Tolyl Chloroformate
CAS No.	937-62-2
Molecular Formula	C8H7ClO2
Molecular Weight	170.59 g/mol
Synonyms	4-Methylphenyl chloroformate; p-Cresyl chloroformate; 4-Tolyl chloroformate; Chloroformic acid 4-methylphenyl ester; p-Tolyl chlorocarbonate; Tosyl Chloroformate (common misnomer); 4-Tolyloxycarbonyl chloride
EINECS	213-340-8

Quality Control

Our p-Tolyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
p-Cresol Content	≤ 1.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.18 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.