Description

Morpholinophosphordichloridite is a versatile organophosphorus reagent primarily used as a key intermediate in the synthesis of complex molecules. Its high reactivity makes it invaluable for constructing phosphoramidite linkages, a critical step in oligonucleotide and peptide synthesis. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular assembly is required.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleoside phosphoramidites for oligonucleotide (DNA/RNA) production, used in antisense therapy, PCR primers, and diagnostics.
• Agrochemical Synthesis: Employed as a phosphorylating agent in the manufacture of specialized pesticides, herbicides, and plant growth regulators.
• Ligand Precursor: Used to synthesize novel phosphine and phosphoramidite ligands for asymmetric catalysis and transition metal complexes.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of flame-retardant polymers and specialty polyphosphazenes.
• Peptide Synthesis: Facilitates the formation of phosphopeptide analogs for biochemical research and drug discovery.
• Chemical Research: A fundamental reagent in academic and industrial R&D for exploring new organophosphorus chemistry and creating novel molecular architectures.

Basic Information

Product Name	Morpholinophosphordichloridite
CAS No.	932-74-1
Molecular Formula	C4H8Cl2NOP
Molecular Weight	188.00 g/mol
Synonyms	Morpholino Phosphorodichloridite; 2-Chloro-4,4,5,5-tetrahydro-1,3,2λ5-oxazaphosphole; Morpholinodichlorophosphine; Dichloromorpholinophosphine; N-(Dichlorophosphino)morpholine; Phosphorodichloridic Acid Morpholide; 4-Morpholinephosphonous Dichloride
EINECS	213-267-6

Quality Control

Our Morpholinophosphordichloridite is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We adhere to cGMP principles where applicable, and our quality system is designed to meet the rigorous demands of pharmaceutical and fine chemical industries. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.