Description

L-Alanine, n-(Dichlorophosphinyl)-, Methyl Ester is a specialized organophosphorus building block derived from the amino acid L-alanine. This compound is valued for its role as a key chiral intermediate in the synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing peptidomimetics and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of protease inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel, chiral active ingredients for herbicides, insecticides, and fungicides.
• Peptidomimetic Chemistry: Serves as a backbone-modified amino acid analog for creating stable peptide mimics with enhanced pharmacological properties.
• Ligand and Catalyst Development: Employed in the preparation of chiral phosphonamide ligands for asymmetric catalysis.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme mechanisms and function.
• Advanced Material Synthesis: A precursor for functionalized polymers and dendrimers with specific chiral architectures.

Basic Information

Product Name	L-Alanine, n-(Dichlorophosphinyl)-, Methyl Ester
CAS No.	145764-71-2
Molecular Formula	C₄H₈Cl₂NO₃P
Molecular Weight	220.99 g/mol
Synonyms	L-Alanine, N-(dichlorophosphinyl)-, methyl ester; Methyl N-(dichlorophosphinyl)-L-alaninate; (S)-Methyl 2-((dichlorophosphoryl)amino)propanoate; Alanine, N-(dichlorophosphinyl)-, methyl ester, L-; L-Alanine methyl ester N-phosphoryl dichloride; N-Dichlorophosphinyl-L-alanine methyl ester; Alanine Phosphorodichloridate Methyl Ester (L-); Phosphoramidic dichloride, N-[(1S)-1-(methoxycarbonyl)ethyl]-
EINECS	Contact for details

Quality Control

Our production of L-Alanine, n-(Dichlorophosphinyl)-, Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity for research and development applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.