Description

Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Chlorophosphine is a specialized organophosphorus compound featuring sterically hindered phenolic groups, making it a valuable ligand and synthetic intermediate. Its primary commercial value lies in its role as a precursor for advanced phosphine ligands used in homogeneous catalysis, particularly in cross-coupling reactions critical for pharmaceutical and fine chemical synthesis. This high-purity chemical is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts.

Application

• Catalyst Ligand Precursor: Key intermediate for synthesizing bulky, electron-rich phosphine ligands used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi).
• Pharmaceutical Intermediate: Employed in the synthesis of complex active pharmaceutical ingredients (APIs) where precise stereochemical control is required.
• Agrochemical Synthesis: Used in creating novel pesticide and herbicide molecules that benefit from the unique steric and electronic properties of derived ligands.
• Polymerization Catalyst Component: Serves as a ligand precursor in olefin polymerization and other transition metal-catalyzed polymerizations.
• Material Science Research: Investigated for the development of novel organometallic complexes and metal-organic frameworks (MOFs).
• Asymmetric Synthesis: Potential building block for chiral phosphine ligands used in enantioselective catalysis.

Basic Information

Product Name	Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Chlorophosphine
CAS No.	212713-08-1
Molecular Formula	C30H46ClO2P
Molecular Weight	505.10 g/mol
Synonyms	Chlorobis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine; (3,5-Di-tert-butyl-4-methoxyphenyl)chlorophosphine dimer; Bis(4-methoxy-3,5-di-tert-butylphenyl)chlorophosphine; Chloro-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane; DTBPMP-Cl; Ligand Precursor DTBPMP
EINECS	Contact for details

Quality Control

Our production of Bis(3,5-Di-tert-Butyl-4-Methoxyphenyl)Chlorophosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive catalytic applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.