Description

Noscapine Hydrochloride CAS NO 912-60-7 is a pharmaceutically active salt form of the naturally occurring alkaloid noscapine. This compound is valued for its non-narcotic antitussive (cough-suppressing) properties and its emerging role as a tubulin-binding agent in research. It is primarily required by the pharmaceutical industry for the formulation of cough medications and by research institutions investigating its potential in areas such as oncology and neuropharmacology.

Application

• Pharmaceutical Active Ingredient (API): Primary use as a non-opioid antitussive agent in prescription and over-the-counter cough syrups and lozenges.
• Clinical Research: Investigation of its mechanism of action as a microtubule-modulating agent for potential cancer therapy applications.
• Biochemical Research: Used as a reference standard and analytical reagent in pharmacokinetic and metabolic studies.
• Preclinical Development: Serves as a key intermediate or target molecule in drug discovery programs focused on tubulin-binding compounds.
• Analytical Standard: Employed in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Product Name	Noscapine Hydrochloride
CAS No.	912-60-7
Molecular Formula	C22H23NO7 • HCl
Molecular Weight	449.88 g/mol
Synonyms	Narcotine Hydrochloride; (-)-Noscapine Hydrochloride; 1-[(3S,4S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonyl]-1(3H)-isobenzofuranone Hydrochloride; Opianine Hydrochloride; Nectadon; Longatin; Tusscapine; α-Narcotine Hydrochloride
EINECS	213-012-7

Quality Control

Our Noscapine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and research applications. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, with specifications that can align with in-house pharmacopeial standards. Our commitment to quality assurance and regulatory compliance ensures reliable and consistent material for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of water vapor.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Specific Rotation	-200° to -220° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.