Description

Metyrapone CAS NO 908-35-0 is a potent and selective inhibitor of the enzyme 11β-hydroxylase, which plays a critical role in the biosynthesis of cortisol and corticosterone. This compound is essential for research and diagnostic applications involving the hypothalamic-pituitary-adrenal (HPA) axis. It is primarily utilized by pharmaceutical researchers, clinical diagnostic laboratories, and academic institutions studying endocrinology and steroid metabolism.

Application

• Endocrine Research: A key tool for studying adrenal steroidogenesis and the regulation of cortisol production in vitro and in vivo.
• Clinical Diagnostics: Used in dynamic testing procedures, such as the metyrapone stimulation test, to assess pituitary reserve and diagnose disorders of the HPA axis.
• Pharmaceutical Development: Serves as a reference standard and pharmacologic agent in the development of new therapies targeting Cushing's syndrome and related endocrine conditions.
• Biochemical Studies: Employed to investigate enzyme inhibition mechanisms and the biochemical pathways of corticosteroid synthesis.

Basic Information

Product Name	Metyrapone
CAS No.	908-35-0
Molecular Formula	C14H14N2O
Molecular Weight	226.27 g/mol
Synonyms	2-Methyl-1,2-di-3-pyridyl-1-propanone; Metopirone; Mepyrapone; SU-4885; Methopyrapone; 2-Methyl-1,2-di(pyridin-3-yl)propan-1-one
EINECS	213-010-5

Quality Control

Our Metyrapone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-purity standards suitable for research and diagnostic use. A Certificate of Analysis (COA) detailing specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.