Description

Thyrotropin-Releasing Hormone (TRH) is a tripeptide hypothalamic hormone that plays a critical role in regulating the endocrine system by stimulating the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary. This compound is essential for research and development in neuroendocrinology and diagnostic applications. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostics manufacturers, and academic research institutions focused on thyroid function, pituitary disorders, and peptide therapeutics.

Application

• Pharmaceutical Research & Development: As a key reference standard and active ingredient in the development of diagnostic assays and potential therapeutic agents for thyroid and pituitary disorders.
• Clinical Diagnostics: Used in the manufacture of in-vitro diagnostic (IVD) kits for assessing pituitary function and thyroid health.
• Neuroendocrine Studies: A vital tool in basic scientific research to investigate the hypothalamic-pituitary-thyroid (HPT) axis, hormone release mechanisms, and related physiological pathways.
• Biochemical Reagent: Serves as a high-purity biochemical reagent for cell culture studies, receptor binding assays, and signal transduction research.
• Peptide Chemistry Reference: Used as a standard in analytical chemistry for method development and validation in peptide analysis via HPLC and mass spectrometry.

Basic Information

Product Name	Thyrotropin-Releasing Hormone
CAS No.	24305-27-9
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	TRH; Thyroliberin; Protirelin; Lopremone; Pyroglutamyl-histidyl-prolinamide; pGlu-His-Pro-NH2; (S)-5-Oxo-1-((S)-2-(5-oxopyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)pyrrolidine-2-carboxamide
EINECS	246-184-1

Quality Control

Our Thyrotropin-Releasing Hormone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with relevant research and pharmaceutical grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.