Description

Cholecystokinin Octapeptide Free Acid (Desulfated), Sincalide (Free Acid) (Desulfated) is a synthetic, desulfated analog of the C-terminal octapeptide of the gastrointestinal hormone cholecystokinin (CCK-8). This high-purity peptide reference standard is critical for pharmaceutical research and development, particularly in studies of the cholecystokinin receptor system. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) for analytical method development, bioassay calibration, and as a key intermediate in advanced peptide synthesis.

Application

• Pharmaceutical Reference Standard: Used for the qualification and calibration of analytical instruments (HPLC, LC-MS) in quality control laboratories.
• Biochemical Research: Serves as a crucial tool for studying CCK receptor binding, signal transduction pathways, and gastrointestinal physiology.
• Drug Discovery & Development: Acts as a key intermediate or a comparative standard in the synthesis and development of novel peptide-based therapeutics targeting metabolic or neurological disorders.
• Academic Research: Employed in university and institutional labs for fundamental research into hormone action, peptide chemistry, and receptor pharmacology.
• Bioassay Calibration: Essential for standardizing cell-based or biochemical assays that measure CCK activity or receptor antagonism.

Basic Information

Product Name	Cholecystokinin Octapeptide Free Acid (Desulfated), Sincalide (Free Acid) (Desulfated)
CAS No.	103974-46-5
Molecular Formula	C₄₉H₆₂N₁₀O₁₆S
Molecular Weight	1071.1 g/mol
Synonyms	Sincalide Free Acid (Desulfated); CCK-8 Free Acid (Desulfated); Cholecystokinin (26-33), Free Acid, Desulfated; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (Free Acid, Desulfated); SQ 19844 Free Acid (Desulfated); CCK Octapeptide Free Acid (Desulfated); Kinevac Free Acid (Desulfated)
EINECS	Contact for details

Quality Control

Our Cholecystokinin Octapeptide Free Acid (Desulfated) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical values
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.