Description

Oxybuprocaine CAS NO 99-43-4 is a potent local anesthetic belonging to the ester class of amino benzoates. This compound is critical for providing rapid and effective surface anesthesia, particularly in sensitive areas where minimal irritation is paramount. It is an essential active pharmaceutical ingredient (API) primarily required by manufacturers in the ophthalmic, otolaryngological, and diagnostic medical device sectors for formulating topical anesthetic solutions and gels.

Application

• Ophthalmic Anesthesia: Primary use in eye drop formulations for procedures like tonometry, cataract surgery, and foreign body removal.
• Otolaryngology (ENT): Used in throat sprays and solutions for anesthesia prior to endoscopic examinations or minor surgical procedures.
• Diagnostic Procedures: Key component in gels and lubricants for anesthesia during transesophageal echocardiography (TEE) and other internal probes.
• Topical Anesthetic Preparations: Formulated into creams, ointments, and solutions for superficial skin procedures and mucous membrane anesthesia.
• Veterinary Medicine: Employed in topical anesthetic products for ocular and superficial procedures in animals.
• Pharmaceutical Intermediates: Serves as a chemical building block for the synthesis of more complex anesthetic agents.

Basic Information

Product Name	Oxybuprocaine
CAS No.	99-43-4
Molecular Formula	C17H28N2O3
Molecular Weight	308.42 g/mol
Synonyms	Benoxinate; Oxibuprocaine; 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate; Novesin; Dorsacaine; Conjuncain; Aneminxin; Cebesine; LIX; 4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester
EINECS	202-758-7

Quality Control

Our Oxybuprocaine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.