Description

Articaine Hydrochloride CAS NO 23964-57-0 is a potent local anesthetic belonging to the amide class, widely recognized for its rapid onset and profound depth of anesthesia. Its primary value lies in providing effective nerve blockade with a favorable safety profile and enhanced diffusion properties compared to other agents. This makes it a critical active pharmaceutical ingredient (API) for manufacturers of injectable anesthetic solutions. It is essential for dental professionals, pharmaceutical companies, and research institutions focused on pain management and surgical procedures.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable local anesthetic formulations for medical and dental use.
• Dental Anesthesia: Key component in solutions for infiltration and nerve block anesthesia in dental surgeries, including extractions, root canals, and periodontal procedures.
• Surgical Anesthesia: Used in minor surgical procedures requiring localized pain control.
• Research & Development: Serves as a reference standard and building block in pharmacological research for developing new anesthetic agents or studying nerve conduction.
• Generic Drug Manufacturing: Essential for companies producing generic versions of articaine-based anesthetic products.
• Veterinary Medicine: Applied in veterinary practices for minor surgical interventions in animals.

Basic Information

Product Name	Articaine Hydrochloride
CAS No.	23964-57-0
Molecular Formula	C13H20N2O3S • HCl
Molecular Weight	320.84 g/mol
Synonyms	4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic Acid Methyl Ester Hydrochloride; Carticaine Hydrochloride; HOE 045; Articaine HCl; (±)-Methyl 4-methyl-3-(2-propylaminopropionamido)-2-thiophenecarboxylate Hydrochloride
EINECS	Contact for details

Quality Control

Our Articaine Hydrochloride is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) compliant with current pharmacopeial guidelines (e.g., USP, EP) are provided with each batch to guarantee traceability, consistency, and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	-0.10° to +0.10°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.