Description

Pramocaine CAS NO 140-65-8 is a synthetic local anesthetic agent belonging to the amino ester class. It is valued for its topical numbing properties and is a key active pharmaceutical ingredient (API) in various therapeutic formulations. This compound is primarily utilized by pharmaceutical manufacturers and research institutions developing products for dermatological and mucosal relief.

Application

• Topical Anesthetic Formulations: Primary use in creams, ointments, gels, and sprays for temporary relief of pain and itching associated with minor skin conditions, hemorrhoids, and anal fissures.
• Dermatological Preparations: Incorporated into medicated products for sunburn, insect bites, poison ivy, and other minor skin irritations.
• Over-the-Counter (OTC) Medications: Serves as the active ingredient in various OTC anti-itch and pain relief products available in pharmacies.
• Veterinary Pharmaceuticals: Used in topical preparations for animals to manage localized pain and pruritus.
• Cosmetic & Personal Care: Potential use in products like after-shave lotions or depilatory creams to reduce discomfort.
• Pharmaceutical Intermediates: Acts as a chemical building block in the synthesis of more complex anesthetic or therapeutic agents.
• Clinical & Biomedical Research: Employed in laboratory studies investigating peripheral nerve block mechanisms and local anesthetic efficacy.

Basic Information

Product Name	Pramocaine
CAS No.	140-65-8
Molecular Formula	C17H27NO3
Molecular Weight	293.41 g/mol
Synonyms	Pramoxine; Pramocaine Hydrochloride (salt form); 4-[3-(4-Butoxyphenoxy)propyl]morpholine; Pramocaine Base; Pramoxine HCl; Proctofoam; Tronolane; Itch-X; Fleet Pain Relief; Americaine Anti-Itch
EINECS	205-427-8

Quality Control

We supply Pramocaine that meets stringent quality standards suitable for pharmaceutical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. We can provide material compliant with relevant pharmacopeial monographs (e.g., USP) based on customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%
Microbiological Enumeration	Meets USP <61> criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.