Description

Bupivacaine Hydrochloride CAS NO 14252-80-3 is a potent, long-acting amino amide-type local anesthetic agent. It is a critical pharmaceutical active ingredient (API) valued for its extended duration of action, providing effective regional anesthesia and analgesia. This compound is essential for manufacturers in the pharmaceutical industry, particularly for the formulation of injectable solutions used in surgical anesthesia, epidural blocks, and postoperative pain management.

Application

• Pharmaceutical API: Primary active ingredient in injectable local anesthetic formulations.
• Surgical Anesthesia: Used for nerve blocks, infiltration, and spinal anesthesia in various surgical procedures.
• Obstetric Analgesia: Key component in epidural solutions for pain relief during labor and delivery.
• Postoperative Pain Management: Employed in regional analgesic techniques to control pain after surgery.
• Therapeutic Pain Relief: Formulated for nerve block injections to manage chronic pain conditions.
• Veterinary Medicine: Used in veterinary practice for local and regional anesthesia in animals.
• Research & Development: Serves as a reference standard and for pharmacological studies in academic and industrial R&D.

Basic Information

Product Name	Bupivacaine Hydrochloride
CAS No.	14252-80-3
Molecular Formula	C₁₈H₂₈N₂O•HCl
Molecular Weight	324.89 g/mol
Synonyms	1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; (±)-1-Butyl-2',6'-pipecoloxylidide hydrochloride; Bupivacaine HCl; Marcaine Hydrochloride; Sensorcaine; Bupivacaine Hydrochloride Anhydrous; Bupivacaine Monohydrochloride; (±)-Bupivacaine Hydrochloride
EINECS	238-152-5

Quality Control

Our Bupivacaine Hydrochloride is manufactured under strict quality management systems. It undergoes rigorous analytical testing to meet high-purity standards, including compliance with major pharmacopoeial monographs such as USP, EP, and BP. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring it is suitable for GMP pharmaceutical production.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive) and should be handled in conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	-0.10° to +0.10°
pH (1% solution)	4.5 - 6.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.