Description

Cyclobutyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone is a high-purity synthetic organic compound featuring a thiophene core functionalized with a ketone and a protected aldehyde group. This specialized structure makes it a valuable advanced pharmaceutical intermediate for the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecular entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Organic Synthesis Reagent: Employed in academic and industrial research for constructing complex heterocyclic frameworks containing thiophene and ketone functionalities.
• Agrochemical Intermediate: Potential use in the development of new crop protection agents and pesticides.
• Material Science Precursor: Can be investigated for the synthesis of organic semiconductors or conductive polymers due to its conjugated thiophene system.

Basic Information

Product Name	Cyclobutyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone
CAS No.	898772-52-6
Molecular Formula	C13H16O3S
Molecular Weight	252.33 g/mol
Synonyms	Cyclobutyl[5-(1,3-dioxolan-2-yl)-2-thienyl]methanone; 2-(5-Cyclobutanecarbonyl-2-thienyl)-1,3-dioxolane; 5-(1,3-Dioxolan-2-yl)-2-thiophenecarboxylic acid cyclobutyl ester; Cyclobutyl 5-(1,3-dioxolan-2-yl)thiophene-2-carboxylate; 898772-52-6; Cyclobutyl 5-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-thienyl ketone (related protected form); Thiophene-dioxolane ketone intermediate
EINECS	Contact for details

Quality Control

Our Cyclobutyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development from milligram to kilogram scale with a commitment to ISO 9001 quality management principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.