Description

2-Trifluoroacetyl-5-(1,3-dioxolan-2-yl)thiophene is a high-value, multifunctional heterocyclic building block characterized by its reactive trifluoroacetyl and protected aldehyde (dioxolane) groups. This compound matters for its critical role in the synthesis of complex molecules, particularly in advanced pharmaceutical research and agrochemical development, where its unique fluorine-containing scaffold imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel thiophene-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the construction of advanced active ingredients for crop protection, leveraging the thiophene moiety for bioactivity.
• Material Science Research: Serves as a precursor for functionalized thiophene monomers in the development of conductive polymers and organic electronic materials.
• Fluorine Chemistry: An essential building block for introducing the trifluoroacetyl group into complex molecular architectures, a common motif in medicinal chemistry.
• Cross-Coupling Reactions: The thiophene ring is amenable to various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for further derivatization.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-Trifluoroacetyl-5-(1,3-dioxolan-2-yl)thiophene
CAS No.	898772-29-7
Molecular Formula	C9H7F3O3S
Molecular Weight	252.21 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-(trifluoroacetyl)thiophene; 2-(Trifluoroacetyl)-5-(1,3-dioxolan-2-yl)thiophene; 5-(1,3-Dioxolan-2-yl)thiophene-2-carbaldehyde, 2,2,2-trifluoro-1-oxoethyl deriv.; Thiophene, 2-(trifluoroacetyl)-5-(1,3-dioxolan-2-yl)-; 898772-29-7; 2-Trifluoroacetyl-5-(1,3-dioxolan-2-yl)thiophene; 5-(1,3-Dioxolan-2-yl)-2-trifluoroacetylthiophene
EINECS	Contact for details

Quality Control

Our 2-Trifluoroacetyl-5-(1,3-dioxolan-2-yl)thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.