Description

4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Fluorobenzophenone is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and benzophenone-based molecular architecture. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic areas. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small-molecule drugs.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel APIs, especially in neuropharmacology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Preclinical Drug Development: Essential for producing compounds for pharmacological evaluation and toxicology studies.
• Synthesis of Receptor Modulators: Its structural features make it valuable for creating ligands targeting specific GPCRs or enzyme systems.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex drug molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Fluorobenzophenone
CAS No.	898758-25-3
Molecular Formula	C25H27ClFNO3
Molecular Weight	443.94 g/mol
Synonyms	2-Fluoro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-4-chlorobenzophenone; 4-Chloro-2-fluoro-4'-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 4'-[(8-Aza-1,4-dioxaspiro[4.5]dec-8-yl)methyl]-4-chloro-2-fluorobenzophenone; Benzophenone, 4-chloro-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-2-fluoro-; CAS 898758-25-3; 898758-25-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Fluorobenzophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.