Description

(1R,2R,4R)-2-Azido-1-Isopropyl-4-Methylcyclohexane is a high-purity, stereochemically defined chiral intermediate of significant interest in advanced organic synthesis. Its value lies in its unique azido functional group and specific stereochemistry, which are critical for constructing complex molecular architectures with precise three-dimensional control. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for applications in click chemistry, peptide mimetics, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting specific biological receptors.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and material surface functionalization.
• Agrochemical Synthesis: Serves as a precursor in the development of stereoselective pesticides and herbicides, where the specific isomer configuration can influence bioactivity.
• Ligand and Catalyst Development: Used to create novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Academic and R&D: A valuable tool for methodological research in organic chemistry, particularly in studies exploring new cycloaddition reactions and stereoselective transformations.
• Material Science: Potential use in the synthesis of functionalized polymers and dendrimers with tailored properties.

Basic Information

Product Name	(1R,2R,4R)-2-Azido-1-Isopropyl-4-Methylcyclohexane
CAS No.	898543-45-8
Molecular Formula	C10H19N3
Molecular Weight	181.28 g/mol
Synonyms	(1R,2R,4R)-2-Azido-1-(1-methylethyl)-4-methylcyclohexane; (1R,2R,4R)-1-Isopropyl-4-methyl-2-azidocyclohexane; 2-Azido-1-isopropyl-4-methylcyclohexane (stereoisomer); trans-2-Azido-1-isopropyl-4-methylcyclohexane; Azidocyclohexane derivative; Chiral azido intermediate; LFA-1 antagonist intermediate (related chemistry)
EINECS	Contact for details

Quality Control

Every batch of (1R,2R,4R)-2-Azido-1-Isopropyl-4-Methylcyclohexane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric excess (ee) and chemical purity as required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this compound should be stored under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). For long-term storage, consider refrigeration (2-8°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.