Description

3',5'-Di-o-tert-Butyldimethylsilyl-2'-Deoxy-8-[(3-Methyl-8-Methyl-3H-Imidazo[4,5-F]Quinoxalin-2-Yl)Amino]-6-o-Benzyl-Guanosine is a sophisticated, multi-protected nucleoside analog designed for advanced oligonucleotide synthesis and medicinal chemistry research. This compound is a critical high-purity building block for the development of novel therapeutic agents, particularly in the fields of oncology and antiviral research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of modified nucleic acids and targeted molecular probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based drug candidates targeting specific enzymes or genetic pathways.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified guanosine analogs into oligonucleotide sequences to enhance stability, binding affinity, and pharmacokinetic properties.
• siRNA and miRNA Research: Serves as a protected monomer for the solid-phase synthesis of RNA strands used in gene silencing and functional genomics studies.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by providing a versatile scaffold for further functionalization.
• Bioconjugation and Probe Development: The reactive handles and protective groups allow for the creation of fluorescently labeled or affinity-tagged nucleotide probes for diagnostic applications.
• Academic Research: Supports fundamental research in nucleic acid chemistry, enzymology, and the mechanism of action of nucleotide analogs.

Basic Information

Product Name	3',5'-Di-o-tert-Butyldimethylsilyl-2'-Deoxy-8-[(3-Methyl-8-Methyl-3H-Imidazo[4,5-F]Quinoxalin-2-Yl)Amino]-6-o-Benzyl-Guanosine
CAS No.	896719-54-3
Molecular Formula	C43H61N9O5Si2
Molecular Weight	840.2 g/mol
Synonyms	8-[(3-Methyl-8-methyl-3H-imidazo[4,5-f]quinoxalin-2-yl)amino]-6-O-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine; 2'-Deoxy-8-[(3-methyl-8-methyl-3H-imidazo[4,5-f]quinoxalin-2-yl)amino]-6-O-benzyl-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine; TBDMS-protected 8-Amino-6-O-Benzyl Guanosine Derivative; Protected dG Analog; 8-AQ Modified Guanosine Building Block
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity essential for sensitive research and development. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.