Description

At9283 CAS NO 896466-04-9 is a potent and selective small-molecule inhibitor primarily targeting Aurora kinases A and B, which are key regulators of the cell cycle. This compound is critical for researchers and developers in the life sciences sector, offering a powerful tool for investigating cell division mechanisms and their dysregulation in diseases. It is essential for pharmaceutical R&D, particularly in oncology for the development of novel anti-cancer therapeutics, as well as for academic research in molecular biology and biochemistry.

Application

• Oncology Research: Used as a key biochemical tool to study the role of Aurora kinases in tumor cell proliferation and to evaluate potential anti-cancer drug candidates.
• Pharmaceutical Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the preclinical development of targeted cancer therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzyme inhibition studies to characterize kinase activity and selectivity profiles.
• Academic Research: Facilitates fundamental studies in cell biology, including mitosis, chromosome segregation, and centrosome function.
• Drug Discovery Programs: Integral to structure-activity relationship (SAR) studies for optimizing next-generation kinase inhibitors.

Basic Information

Product Name	At9283
CAS No.	896466-04-9
Molecular Formula	C₂₁H₂₃N₇O₂
Molecular Weight	405.46 g/mol
Synonyms	AT-9283; AT 9283; 1H-Pyrrolo[2,3-b]pyridine, 3-[5-[[[4-(4-methyl-1-piperazinyl)phenyl]amino]carbonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-; Aurora Kinase Inhibitor AT9283; 3-(5-((4-(4-Methylpiperazin-1-yl)phenyl)carbamoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine; UNII-3Q8I5K5E6F; 3Q8I5K5E6F
EINECS	Contact for details

Quality Control

Our At9283 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic identification (NMR, MS). We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.