Description

Flumatinib Mesylate is a potent and selective small-molecule tyrosine kinase inhibitor. This high-purity active pharmaceutical ingredient (API) is critical for targeted cancer therapy research and development. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and formulation.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of targeted anti-cancer therapeutics.
• Oncology Research: Critical reference standard and biochemical tool for studying BCR-ABL tyrosine kinase inhibition in chronic myeloid leukemia (CML) and other cancers.
• Preclinical & Clinical Development: Used in the development and manufacturing of drug candidates during preclinical studies and clinical trials.
• Drug Discovery: Serves as a key intermediate or lead compound in medicinal chemistry programs for novel kinase inhibitors.
• Analytical Standard: High-purity material used for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.

Basic Information

Product Name	Flumatinib Mesylate
CAS No.	895519-91-2
Molecular Formula	C₂₉H₃₂F₃N₇O₃ • CH₄O₃S
Molecular Weight	687.73 g/mol
Synonyms	Flumatinib Methanesulfonate; HH-GV-678 Mesylate; N-[3-[[6,7-Bis(2-methoxyethoxy)-4-quinazolinyl]amino]-4-methylphenyl]-4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide methanesulfonate; GZD824 Mesylate; (R)-N-(3-((6,7-Bis(2-methoxyethoxy)quinazolin-4-yl)amino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate; HHGV678 Mesylate
EINECS	Contact for details

Quality Control

Our Flumatinib Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and APIs. A Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.