Description

Flumatinib is a potent and selective tyrosine kinase inhibitor primarily targeting Bcr-Abl, including its mutant forms. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is a critical intermediate and reference standard for researchers and manufacturers in the oncology and hematology sectors, particularly those developing next-generation targeted cancer therapies.

Application

• Primary use as a pharmaceutical reference standard for analytical method development and validation.
• Critical active pharmaceutical ingredient (API) intermediate in the synthesis of targeted cancer therapeutics.
• Biochemical research tool for studying Bcr-Abl kinase signaling pathways and mechanisms of drug resistance.
• Pre-clinical and clinical research material for oncology drug discovery programs.
• Used in the development of assay kits and diagnostic reagents related to tyrosine kinase activity.

Basic Information

Product Name	Flumatinib
CAS No.	895519-90-1
Molecular Formula	C₂₃H₂₆FN₇O₂
Molecular Weight	451.50 g/mol
Synonyms	Flumatinib; HH-GV-678; (R)-N-(3-(4-(7-(3-(4-Ethylpiperazin-1-yl)propoxy)quinazolin-4-ylamino)phenyl)acryloyl)-4-fluorobenzamide; 4-fluoro-N-[(1R)-2-[4-[[7-[3-(4-ethylpiperazin-1-yl)propoxy]-4-quinazolinyl]amino]phenyl]-1-(hydroxymethyl)-2-oxoethyl]benzamide; ABL001 analog; Bcr-Abl inhibitor
EINECS	Contact for details

Quality Control

Our Flumatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.