Description

3-Chloroisonicotinoyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its bifunctional chlorocarbonyl and chloropyridine structure makes it a critical building block for constructing complex molecules with precision. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to introduce the 3-chloroisonicotinate moiety into target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloronicotinoyl group confers specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic materials with tailored electronic or photophysical properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Chloroisonicotinoyl Chloride
CAS No.	895128-46-8
Molecular Formula	C6H3Cl2NO
Molecular Weight	176.00 g/mol
Synonyms	3-Chloroisonicotinic acid chloride; 3-Chloro-4-pyridinecarbonyl chloride; 3-Chloropyridine-4-carbonyl chloride; Isonicotinoyl chloride, 3-chloro-; 4-Pyridinecarbonyl chloride, 3-chloro-; 3-Chloro-4-pyridylcarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloroisonicotinoyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.