Description

(2S,4S)-4-Azidopyrrolidine-2-Carboxylic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative featuring a strategically positioned azide functional group. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling advanced synthetic methodologies. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications such as peptide mimetics, PROTACs, and bioconjugation via click chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly protease inhibitors and other bioactive molecules.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and novel functionality into peptide backbones to enhance stability and biological activity.
• Bioconjugation & Click Chemistry: The azide group enables efficient, site-specific labeling of biomolecules (proteins, antibodies, oligonucleotides) via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC).
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a versatile linker component, connecting an E3 ligase ligand to a target protein ligand to facilitate targeted protein degradation.
• Chemical Biology Probes: Employed in the development of activity-based probes and tools for studying enzyme function and cellular pathways.
• Material Science & Polymer Chemistry: Acts as a functional monomer for creating specialized polymers with tailored properties via post-polymerization modification.

Basic Information

Product Name	(2S,4S)-4-Azidopyrrolidine-2-Carboxylic Acid Hydrochloride
CAS No.	892128-58-4
Molecular Formula	C5H8N4O2 • HCl
Molecular Weight	192.60 g/mol (Free base: 156.14 g/mol)
Synonyms	(2S,4S)-4-Azidoproline hydrochloride; 4-Azido-L-proline hydrochloride; (2S,4S)-4-Azidopyrrolidine-2-carboxylic acid HCl; 4-Azidopyrrolidine-2-carboxylic acid hydrochloride, (2S,4S)-; L-4-Azidoproline hydrochloride; Azidoproline HCl; (4S)-4-Azidopyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Azidopyrrolidine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, NMR, and MS data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.