Description

Custirsen CAS NO 890056-27-6 is a second-generation antisense oligonucleotide designed to inhibit the production of clusterin, a cytoprotective chaperone protein. This compound is of significant interest in oncology research and development due to its potential to enhance the efficacy of standard cancer therapies by overcoming treatment resistance. It is primarily utilized by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in the development of novel therapeutic agents for prostate cancer, non-small cell lung cancer, and other malignancies.

Application

• Oncology Research: Investigational agent in clinical and preclinical studies for various cancers, including castration-resistant prostate cancer (CRPC) and non-small cell lung cancer (NSCLC).
• Therapeutic Development: Key component in the formulation and development of novel antisense-based cancer therapeutics.
• Mechanistic Studies: Used in laboratory research to study the role of clusterin in apoptosis inhibition, treatment resistance, and tumor progression.
• Combination Therapy Research: Employed in studies to evaluate synergistic effects when combined with chemotherapy, radiation, or hormone therapy.
• Biopharmaceutical Manufacturing: Serves as an active pharmaceutical ingredient (API) in the GMP production of clinical trial materials.
• Drug Delivery System Development: Used in research focused on optimizing the delivery, stability, and targeting of oligonucleotide drugs.

Basic Information

Product Name	Custirsen
CAS No.	890056-27-6
Molecular Formula	C204H247N63O122P20S20
Molecular Weight	5934.8 g/mol (approximate)
Synonyms	OGX-011; Custirsen sodium; ISIS 112989; TV-1011; Apatorsen; 2'-O-(2-Methoxyethyl) modified antisense oligonucleotide targeting clusterin mRNA; CLU antisense oligonucleotide
EINECS	Contact for details

Quality Control

Our Custirsen is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assessment, and quantification of related substances and impurities. A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment. We support development from preclinical stages through to cGMP-grade material for clinical trial use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere. Keep containers tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (UV)	90.0% - 110.0% of label claim
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Endotoxin (LAL)	< 10 EU/mg (for applicable grades)
Sterility	Sterile (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.