Description

5-Methyl-1,3,4-Oxadiazole-2-Carbonyl Chloride is a highly reactive and versatile acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 5-methyl-1,3,4-oxadiazole moiety into target molecules, a heterocyclic scaffold of significant pharmaceutical interest. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates containing the 1,3,4-oxadiazole ring, which is associated with a wide range of biological activities including antimicrobial, anti-inflammatory, and anticancer properties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the oxadiazole structure can enhance efficacy and environmental profile.
• Material Science Precursor: Employed in the creation of specialized polymers, liquid crystals, and organic electronic materials that require specific heterocyclic functionalities.
• Peptide Mimetics & Bioconjugation: Acts as an acylating agent for modifying peptides or creating stable amide bonds with amines in complex molecular architectures.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new chemical reactions and synthesizing libraries of compounds for screening.
• Scale-Up & Process Chemistry: Suitable for optimization in pilot plant and manufacturing-scale processes for the production of high-value specialty chemicals.

Basic Information

Product Name	5-Methyl-1,3,4-Oxadiazole-2-Carbonyl Chloride
CAS No.	889131-28-6
Molecular Formula	C4H3ClN2O2
Molecular Weight	146.53 g/mol
Synonyms	2-(Chlorocarbonyl)-5-methyl-1,3,4-oxadiazole; 5-Methyl-1,3,4-oxadiazole-2-carbonyl chloride; 5-Methyl-1,3,4-oxadiazole-2-carboxylic acid chloride; 2-Oxadiazolecarbonyl chloride, 5-methyl-; 1,3,4-Oxadiazole-2-carbonyl chloride, 5-methyl-; 5-Methyl-[1,3,4]oxadiazole-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-1,3,4-Oxadiazole-2-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch, and custom specifications can be developed to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.