Description

Ganetespib CAS NO 888216-25-9 is a potent and selective small-molecule inhibitor of Heat Shock Protein 90 (Hsp90), a molecular chaperone critical for the stability and function of numerous oncogenic client proteins. This targeted mechanism makes it a valuable research tool and a compound of significant interest in oncology drug discovery. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics.

Application

• Oncology Research & Drug Discovery: As a key chemical probe for studying Hsp90 inhibition and its effects on cancer cell proliferation, apoptosis, and tumor growth.
• Biochemical Assay Development: Used as a reference standard or active pharmaceutical ingredient (API) in high-throughput screening (HTS) and in vitro efficacy studies.
• Mechanism of Action Studies: Investigating signal transduction pathways dependent on Hsp90 client proteins (e.g., HER2, EGFR, AKT, BRAF) in various cancer models.
• Preclinical Development: Serves as a lead compound or benchmark in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies for novel Hsp90 inhibitors.
• Combination Therapy Research: Exploring synergistic effects when used alongside chemotherapy, radiotherapy, or other targeted agents.

Basic Information

Product Name	Ganetespib
CAS No.	888216-25-9
Molecular Formula	C₃₁H₃₀N₄O₄
Molecular Weight	522.60 g/mol
Synonyms	STA-9090; (2E)-N,N-Dimethyl-2-[(5-{4-methyl-6-[(phenylamino)carbonyl]-1H-benzimidazol-2-yl}-2-furanyl)methylene]hydrazinecarboxamide; Ganetespid; Hsp90 inhibitor STA-9090
EINECS	Contact for details

Quality Control

Our Ganetespib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure compliance with research-grade specifications and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.