Description

Bafetinib is a potent and selective small-molecule inhibitor of the Bcr-Abl and Lyn tyrosine kinases, primarily developed for targeted cancer therapy. This compound is of significant interest in pharmaceutical research and development for its potential in treating chronic myeloid leukemia (CML) and other Bcr-Abl positive leukemias. It is a critical intermediate and reference standard for researchers and manufacturers in the oncology drug discovery and pharmaceutical synthesis sectors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted cancer therapeutics.
• Oncology Research: Reference standard and active compound for in vitro and in vivo studies on Bcr-Abl and Lyn kinase inhibition.
• Drug Discovery & Development: Used in high-throughput screening, mechanism of action studies, and preclinical development of novel kinase inhibitors.
• Biochemical Assays: Essential reagent for enzymatic assays to study kinase activity and signal transduction pathways.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and medicinal chemistry research.
• GMP Manufacturing: Serves as a starting material or intermediate in the cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Bafetinib
CAS No.	887650-05-7
Molecular Formula	C30H31N7O2
Molecular Weight	521.62 g/mol
Synonyms	INNO-406; NS-187; INN-406; UNII-3K0S2JQ5QH; (3R)-3-[4-(1H-Imidazol-1-yl)phenyl]-6-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]-1,3-benzoxazol-2(3H)-one; 1,3-Benzoxazol-2(3H)-one, 3-[4-(1H-imidazol-1-yl)phenyl]-6-[2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]-, (3R)-
EINECS	Contact for details

Quality Control

Our Bafetinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with standards applicable for research and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.