Description

2-Bromoisonicotinoyl Chloride is a versatile and highly reactive halogenated nicotinoyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 2-bromoisonicotinoyl moiety, a key structural motif for modulating biological activity and material properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in cross-coupling and other catalytic reactions.
• Material Science Research: Employed in the synthesis of functional polymers, liquid crystals, and organic electronic materials due to its reactive acid chloride group and aromatic bromine.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse client projects.

Basic Information

Item	Details
Product Name	2-Bromoisonicotinoyl Chloride
CAS No.	887578-70-3
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	2-Bromoisonicotinic acid chloride; 2-Bromo-4-pyridinecarbonyl chloride; 2-Bromopyridine-4-carbonyl chloride; 4-Pyridinecarbonyl chloride, 2-bromo-; Isonicotinoyl chloride, 2-bromo-; 2-Bromo-4-(chlorocarbonyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromoisonicotinoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.