Description

Mapracorat is a synthetic glucocorticoid receptor agonist with potent anti-inflammatory and immunomodulatory properties. This compound is of significant interest for its targeted mechanism of action and potential for topical application. It is primarily utilized by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions engaged in the development of novel dermatological and ophthalmic therapeutics.

Application

• Pharmaceutical R&D: A key intermediate or active pharmaceutical ingredient (API) in the development of novel topical anti-inflammatory drugs.
• Dermatology: Research into treatments for inflammatory skin conditions such as atopic dermatitis, psoriasis, and contact dermatitis.
• Ophthalmology: Investigation of formulations for treating ocular surface inflammation, including allergic conjunctivitis and dry eye disease.
• Mechanistic Studies: Used as a selective tool compound in preclinical research to study glucocorticoid receptor-mediated pathways and their effects.
• Formulation Development: Serves as a model compound for developing creams, ointments, gels, or ophthalmic solutions with optimized drug delivery profiles.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Mapracorat
CAS No.	887375-26-0
Molecular Formula	C₂₄H₂₇F₂N₃O₄
Molecular Weight	459.49 g/mol
Synonyms	ZK-245186; BOL-303242-X; (8S,11R,13S,14S,17R)-17-(2-Fluoroacetyl)-11-fluoro-13-methyl-3-oxo-2,6,7,8,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl 2-(methylamino)benzoate; 2-[(8S,11R,13S,14S,17R)-17-(2-Fluoroacetyl)-11-fluoro-13-methyl-3-oxo-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]oxy-N-methylbenzamide
EINECS	Contact for details

Quality Control

Our Mapracorat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and MS. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.