Description

Uridine, 5'-(2-Methylpropanoate) (9Ci) CAS NO 886538-48-3 is a chemically modified nucleoside derivative where the 5'-hydroxyl group of uridine is esterified with 2-methylpropanoic acid (isobutyric acid). This modification is crucial for enhancing the lipophilicity and membrane permeability of the nucleoside, making it a valuable intermediate in advanced pharmaceutical and biochemical research. It is primarily sought after by researchers and manufacturers in the life sciences sector for the synthesis of prodrugs, nucleotide analogs, and other bioactive compounds. The compound's specific structure allows for targeted delivery and improved metabolic stability in therapeutic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleotide prodrugs.
• Biochemical Research: Used in studies investigating nucleoside metabolism, enzyme mechanisms, and as a precursor for labeled compounds.
• Prodrug Development: The ester moiety facilitates the design of prodrugs to improve the oral bioavailability and tissue distribution of parent nucleoside drugs.
• Nucleic Acid Chemistry: Serves as a modified monomer for oligonucleotide synthesis, enabling the study of structure-activity relationships.
• Diagnostic Agent Synthesis: Potential intermediate in creating molecular probes and contrast agents for diagnostic imaging.

Basic Information

Product Name	Uridine, 5'-(2-Methylpropanoate) (9Ci)
CAS No.	886538-48-3
Molecular Formula	C13H18N2O7
Molecular Weight	314.29 g/mol
Synonyms	5'-O-Isobutyryluridine; Uridine 5'-isobutyrate; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-((isobutyryloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-(2-Methylpropanoyl)uridine; 9CI Uridine, 5'-(2-methylpropanoate); Isobutyric acid uridine-5'-yl ester
EINECS	Contact for details

Quality Control

Our Uridine, 5'-(2-Methylpropanoate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements. Specifications are designed to meet the high standards of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.