Description

Cytidine, 5'-(2-Methylpropanoate) (9Ci) is a chemically modified nucleoside derivative where the 5'-hydroxyl group of cytidine is esterified with 2-methylpropanoic acid (isobutyric acid). This modification is crucial for enhancing the lipophilicity and membrane permeability of the nucleoside, making it a valuable intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral agents, anticancer prodrugs, and other nucleotide-based therapeutics. The compound, identified by CAS number 886538-46-1, represents a high-purity building block for cutting-edge medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside analog prodrugs, particularly for antiviral and anticancer applications.
• Antiviral Drug Research: Used in the development of modified nucleosides targeting viruses such as hepatitis C (HCV) and other RNA viruses.
• Prodrug Synthesis: The ester moiety serves as a protecting group or as part of a prodrug strategy to improve the bioavailability and pharmacokinetic profile of active nucleoside drugs.
• Biochemical Research: Tool compound for studying nucleoside metabolism, enzyme inhibition, and cellular uptake mechanisms.
• Medicinal Chemistry: Intermediate for structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of nucleotide-based therapeutics.
• Labeled Compound Precursor: Potential starting material for the synthesis of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and analytical standards.

Basic Information

Item	Detail
Product Name	Cytidine, 5'-(2-Methylpropanoate) (9Ci)
CAS No.	886538-46-1
Molecular Formula	C13H19N3O6
Molecular Weight	313.31 g/mol
Synonyms	5'-O-Isobutyrylcytidine; Cytidine 5'-isobutyrate; 5'-Isobutyrylcytidine; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-((2-methylpropanoyl)oxy)tetrahydrofuran-2-yl)-4-imino-1,4-dihydropyrimidin-2(3H)-one; 5'-O-(2-Methyl-1-oxopropoxy)cytidine; Isobutyric acid cytidin-5'-yl ester
EINECS	Contact for details

Quality Control

Our Cytidine, 5'-(2-Methylpropanoate) (9Ci) is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general reagent standards, specifications can be tailored to align with customer-specific requirements or early-phase drug development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.