Description

2-Methoxy-4,6-Bis(trifluoromethyl)benzoyl chloride is a highly functionalized benzoyl chloride derivative, distinguished by its methoxy and trifluoromethyl substituents. This compound is a critical high-value building block in advanced organic synthesis, prized for introducing electron-deficient aromatic systems with enhanced lipophilicity and metabolic stability. It is primarily sought after by pharmaceutical R&D and agrochemical laboratories for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials requiring specific electronic properties.
• Custom Synthesis & Contract Manufacturing: An essential reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies serving the life sciences sector.

Basic Information

Product Name	2-Methoxy-4,6-Bis(trifluoromethyl)benzoyl chloride
CAS No.	886503-47-5
Molecular Formula	C11H5ClF6O2
Molecular Weight	318.60 g/mol
Synonyms	2-Methoxy-α,α,α,α',α',α'-hexafluoro-4,6-xylene-α-carbonyl chloride; 4,6-Bis(trifluoromethyl)-2-methoxybenzoyl chloride; 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid chloride; 2-Methoxy-4,6-di(trifluoromethyl)benzoyl chloride; 4,6-Bis(trifluoromethyl)-o-anisoyl chloride; Benzoyl chloride, 2-methoxy-4,6-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-2-methoxy-4,6-xylene-α-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Methoxy-4,6-Bis(trifluoromethyl)benzoyl chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.