Description

3-Chloro-5-(Trifluoromethoxy)Benzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of chloro and trifluoromethoxy substituents, which are instrumental in modulating the lipophilicity, metabolic stability, and biological activity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances product efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating specialized aromatic cores in electronic and display materials.
• Polymer Modification: Employed to introduce functional benzoate groups into polymer chains, altering material properties for specialty coatings and engineering plastics.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.
• Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and structure-activity relationships (SAR).

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Benzoyl Chloride
CAS No.	886503-20-4
Molecular Formula	C8H3Cl2F3O2
Molecular Weight	259.01 g/mol
Synonyms	3-Chloro-5-(trifluoromethoxy)benzoyl chloride; 3-Chloro-α,α,α-trifluoro-5-methoxybenzoyl chloride; 5-(Trifluoromethoxy)isophthaloyl chloride (partial); 3-Chloro-5-trifluoromethoxybenzoic acid chloride; Benzoyl chloride, 3-chloro-5-(trifluoromethoxy)-; 886503-20-4; 3-Chloro-5-(trifluoromethoxy)benzoic acid chloride
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Trifluoromethoxy)Benzoyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for pharmaceutical applications and meets the rigorous standards required for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Acid Value	Contact for details
Density	~1.55 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.