Description

5-Methyl-2-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, making it indispensable for developing high-performance materials and active compounds. This intermediate is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine-containing motifs into their products.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing active pharmaceutical ingredients (APIs) with enhanced bioavailability and metabolic stability, particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic cores in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Employed to introduce fluorinated side chains into polymers, enhancing chemical resistance, thermal stability, and surface properties.
• Dye & Pigment Manufacturing: Intermediate for creating specialized fluorinated dyes and pigments with superior lightfastness and color properties.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.

Basic Information

Item	Details
Product Name	5-Methyl-2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	886502-66-5
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	2-Methyl-5-(trifluoromethyl)benzoyl chloride; α,α,α-Trifluoro-2-methyl-5-toluoyl chloride; 5-(Trifluoromethyl)-o-toluoyl chloride; 2-Methyl-α,α,α-trifluoro-m-toluoyl chloride; 5-Methyl-2-trifluoromethylbenzoyl chloride; 2-Methyl-5-trifluoromethylbenzoyl chloride; m-Toluic acid, α,α,α-trifluoro-, acid chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Methyl-2-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets high-purity specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.