Description

4-Bromo-5-Chloro-2-Methylphenyl Isothiocyanate is a versatile and highly reactive organic building block, essential for the synthesis of complex heterocyclic compounds. Its core value lies in its ability to introduce the isothiocyanate functional group, a key precursor for thiourea and thiazole derivatives, enabling advanced research and development. This intermediate is critically needed by pharmaceutical, agrochemical, and advanced material scientists for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in the synthesis of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of new-generation herbicides, fungicides, and pesticides with targeted modes of action.
• Ligand and Chelator Development: Serves as a precursor for creating specialized thiourea-based ligands used in catalysis and metal ion complexation.
• Heterocyclic Chemistry: Fundamental building block for constructing complex sulfur- and nitrogen-containing heterocycles like benzothiazoles and thiadiazoles.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or binding properties.
• Chemical Biology Probes: Useful for modifying biomolecules or creating activity-based probes for studying enzymatic processes.

Basic Information

Product Name	4-Bromo-5-Chloro-2-Methylphenyl Isothiocyanate
CAS No.	886501-19-5
Molecular Formula	C9H5BrClNS
Molecular Weight	290.57 g/mol
Synonyms	1-Bromo-2-chloro-4-isothiocyanato-5-methylbenzene; 2-Methyl-4-bromo-5-chlorophenyl isothiocyanate; 4-Bromo-5-chloro-o-tolyl isothiocyanate; (4-Bromo-5-chloro-2-methylphenyl) isothiocyanate; NSC 886501; 886501-19-5; 5-Chloro-4-bromo-2-methylphenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Chloro-2-Methylphenyl Isothiocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.