Description

4-Fluoro-3-(trifluoromethoxy)benzoyl chloride is a highly reactive and versatile fluorinated aromatic acid chloride intermediate. This compound is critical for introducing the 4-fluoro-3-(trifluoromethoxy)benzoyl moiety into more complex molecules, enabling the synthesis of advanced materials and active ingredients. It is primarily sought by research and development teams, as well as production chemists, in the pharmaceutical and agrochemical industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to improved biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of specialty polymers.
• Organic Synthesis Reagent: A valuable reagent in academic and industrial laboratories for Friedel-Crafts acylation and other coupling reactions to construct complex aromatic systems.
• Material Science Research: Used in the development of organic semiconductors, photovoltaic materials, and other electronic chemicals where specific electron-withdrawing groups are required.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethoxy)benzoyl chloride
CAS No.	886501-08-2
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	4-Fluoro-3-(trifluoromethoxy)benzoic acid chloride; 4-Fluoro-alpha,alpha,α-trifluoro-3-(trifluoromethoxy)benzoyl chloride; 3-(Trifluoromethoxy)-4-fluorobenzoyl chloride; 886501-08-2; Benzoyl chloride, 4-fluoro-3-(trifluoromethoxy)-; 4-Fluoro-3-trifluoromethoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethoxy)benzoyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.