Description

6-Chloro-2-Fluoro-3-Methoxybenzoyl Chloride is a high-purity aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual reactive sites, enabling efficient construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated methoxybenzoyl motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the chloro-fluoro-methoxy substitution pattern contributes to biological activity and environmental stability.
• Ligand and Material Science: Building block for creating specialized ligands for catalysis and monomers for high-performance polymers.
• Chemical Research & Development: A versatile reagent for introducing the 6-chloro-2-fluoro-3-methoxybenzoyl group into various scaffolds during exploratory chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or ISO quality systems.

Basic Information

Product Name	6-Chloro-2-Fluoro-3-Methoxybenzoyl Chloride
CAS No.	886499-63-4
Molecular Formula	C9H5Cl2FO2
Molecular Weight	247.04 g/mol
Synonyms	2-Fluoro-6-chloro-3-methoxybenzoyl chloride; 3-Methoxy-2-fluoro-6-chlorobenzoyl chloride; 6-Chloro-2-fluoro-3-methoxybenzoic acid chloride; 886499-63-4; Benzoyl chloride, 6-chloro-2-fluoro-3-methoxy-; 2-Fluoro-6-chloro-m-anisoyl chloride
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Fluoro-3-Methoxybenzoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to ISO 9001 standards, and we support development and commercial scale requirements. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This product is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.