Description

3,5-Difluoro-2-Methoxybenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 3,5-difluoro-2-methoxybenzoyl moiety into target molecules, enabling the development of compounds with enhanced biological activity and specific physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy aromatic structure confers improved activity and selectivity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated aromatic compounds for electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or modifying agent for creating specialty polymers with specific thermal, optical, or surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new reaction pathways and creating novel fluorinated compounds for various applications.
• Peptide & Protein Modification: Utilized as an acylating agent to modify peptides or other biomolecules, introducing the aromatic fluorinated group for study or functionalization.

Basic Information

Product Name	3,5-Difluoro-2-Methoxybenzoyl Chloride
CAS No.	886498-80-2
Molecular Formula	C9H5ClF2O2
Molecular Weight	218.58 g/mol
Synonyms	2-Methoxy-3,5-difluorobenzoyl chloride; 3,5-Difluoro-2-methoxybenzoic acid chloride; 3,5-Difluoro-o-anisoyl chloride; 2-Methoxy-3,5-difluorobenzoic acid chloride; Benzoic acid, 3,5-difluoro-2-methoxy-, chloride; 886498-80-2; 3,5-Difluoro-2-methoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methoxybenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) in a sealed container to prevent degradation from moisture and ensure stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.