Description

3-Fluoro-5-Methylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value proposition lies in enabling the efficient introduction of the 3-fluoro-5-methylbenzoyl moiety, a key structural motif for modulating the biological activity and physical properties of target molecules. This intermediate is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and methyl substituents enhance bioactivity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer & Specialty Chemical Modification: Employed to introduce functional groups into polymer chains or specialty chemicals to alter solubility, thermal stability, or reactivity.
• Peptide & Protein Conjugation: Utilized as an acylating agent for modifying peptides, proteins, or other biomolecules in biochemical research and diagnostic reagent development.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex fluorinated dyes and high-performance pigments.

Basic Information

Product Name	3-Fluoro-5-Methylbenzoyl Chloride
CAS No.	886497-77-4
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	3-Fluoro-5-methylbenzoyl chloride; 3-Fluoro-5-methyl-benzoic acid chloride; 5-Methyl-3-fluorobenzoyl chloride; m-Fluoro-m-methylbenzoyl chloride; 3-Fluoro-5-methylbenzene-1-carbonyl chloride; 886497-77-4; 3-Fluoro-5-methyl benzoic acid chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Methylbenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.