Description

3-Chloro-5-(Trifluoromethyl)Benzyl Alcohol CAS NO 886496-87-3 is a high-purity fluorinated benzyl alcohol derivative, serving as a critical chiral intermediate and building block in advanced organic synthesis. Its value lies in the unique combination of the chloro and trifluoromethyl substituents, which impart desirable electronic and steric properties for modifying the pharmacokinetic profiles of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and material science for structure-activity relationship (SAR) studies and scaffold diversification.
• Custom Synthesis & Contract Manufacturing: Supplied as a high-purity starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Item	Details
Product Name	3-Chloro-5-(Trifluoromethyl)Benzyl Alcohol
CAS No.	886496-87-3
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	[3-Chloro-5-(trifluoromethyl)phenyl]methanol; (3-Chloro-5-trifluoromethylphenyl)methanol; 3-Chloro-α-(trifluoromethyl)benzenemethanol; 1-Chloro-3-(hydroxymethyl)-5-(trifluoromethyl)benzene; 3-Chloro-5-(trifluoromethyl)benzylalcohol; 886496-87-3; 3-Chloro-5-trifluoromethyl benzyl alcohol
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with ICH guidelines and supports development from research to commercial scale under current Good Manufacturing Practice (cGMP) where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.