Description

3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of chloro and trifluoromethyl substituents, which are instrumental in modulating the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce key functional groups into complex intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the benzoyl moiety with halogen and fluorine substitution for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Building block for herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved lipophilicity and pest control efficacy.
• Liquid Crystal & OLED Material Production: Used in the manufacture of advanced electronic materials and dyes, leveraging its aromatic core for constructing complex conjugated systems.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers, including polyamides and polyesters with unique thermal and chemical resistance properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the 3-chloro-5-(trifluoromethyl)benzoyl group into various aromatic and heteroaromatic scaffolds.
• Chemical Research & Development: Serves as a standard reagent in R&D laboratories for exploring new synthetic methodologies and creating novel compound libraries for screening.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	886496-83-9
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)benzoyl chloride; 3-Chloro-alpha,alpha,α-trifluoro-m-toluoyl chloride; m-Chloro-alpha,alpha,α-trifluorotoluoyl chloride; 3-Chloro-5-(trifluoromethyl)benzoic acid chloride; Benzoyl chloride, 3-chloro-5-(trifluoromethyl)-; 886496-83-9; 3-Chloro-α,α,α-trifluoro-m-toluoyl chloride
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for sensitive synthetic applications. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.