Description

2'-Methyl-2,2,2,4'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl and tetrafluoro-substituted aromatic ring, making it a critical precursor for constructing complex molecules with enhanced properties. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated motifs that can improve metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethylphenyl or related fluorinated aryl ketone groups.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where fluorine atoms enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic electronic materials for their unique electronic properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the behavior of polyfluorinated aromatic systems.

Basic Information

Product Name	2'-Methyl-2,2,2,4'-Tetrafluoroacetophenone
CAS No.	886370-02-1
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(2-Methyl-3,5-difluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-methyl-3,5-difluorophenyl)ethanone; 2-Methyl-3,5-difluoro-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-2'-methyl-3',5'-difluoroacetophenone; 2-Methyl-3,5-difluorophenyl trifluoromethyl ketone; 886370-02-1; 2'-Methyl-2,2,2,4'-tetrafluoro acetophenone
EINECS	Contact for details

Quality Control

Our 2'-Methyl-2,2,2,4'-Tetrafluoroacetophenone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and scale-up applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.