Description

1-(4-Bromo-3-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce trifluoromethyl ketone and halogenated aryl motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Chemical Biology Probes: Utilized to synthesize activity-based probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	1-(4-Bromo-3-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	886369-87-5
Molecular Formula	C8H3BrF4O
Molecular Weight	271.01 g/mol
Synonyms	4'-Bromo-3'-fluoro-2,2,2-trifluoroacetophenone; 1-(4-Bromo-3-fluorophenyl)-2,2,2-trifluoroethanone; 4-Bromo-3-fluoro-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-bromo-3-fluorophenyl)ethanone; 4-Bromo-3-fluorophenyl trifluoromethyl ketone; (4-Bromo-3-fluorophenyl)(trifluoromethyl)methanone; α,α,α-Trifluoro-4'-bromo-3'-fluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-3-Fluoro-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.