Description

5-Methylnicotinoyl Chloride is a versatile and highly reactive chemical intermediate, specifically an acid chloride derivative of nicotinic acid. Its core value proposition lies in enabling efficient and high-yield synthesis of amides and esters, which are critical building blocks in advanced chemical manufacturing. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require a reliable and pure reagent for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of nicotinamide and pyridine-based drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require the 5-methylnicotinoyl moiety for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce functional pyridine groups into polymer chains, enhancing material properties like adhesion, UV stability, and metal chelation.
• Bioconjugation and Probe Development: Useful in biochemical research for labeling proteins, peptides, or other biomolecules via amide bond formation.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Methylnicotinoyl Chloride
CAS No.	884494-95-5
Molecular Formula	C7H6ClNO
Molecular Weight	155.58 g/mol
Synonyms	5-Methylnicotinic acid chloride; 5-Methylpyridine-3-carbonyl chloride; 3-(Chlorocarbonyl)-5-methylpyridine; 5-Methylnicotinyl chloride; 5-Methyl-3-pyridinecarbonyl chloride; Nicotinic acid, 5-methyl-, chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Methylnicotinoyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from moisture, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.