Description

Polygalasaponin F is a bioactive saponin compound isolated from the roots of Polygala tenuifolia and related species. This high-purity reference standard is critical for pharmaceutical research and quality control, enabling precise analysis and development of novel therapeutics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and academic sectors for analytical, pharmacological, and product development purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of herbal extracts and finished products in quality control laboratories.
• Bioactivity Research: Serves as a key compound in pharmacological studies investigating neuroprotective, anti-inflammatory, antidepressant, and cognitive-enhancing effects.
• Natural Product Development: Acts as a marker compound for the standardization and authentication of Polygala tenuifolia (Yuan Zhi) extracts used in dietary supplements and traditional medicine formulations.
• Analytical Method Development: Essential for developing and validating HPLC, UPLC, and LC-MS/MS methods for the quantification of saponins in complex matrices.
• Academic Research: Employed in university and institutional labs for studying the structure-activity relationships (SAR) of triterpenoid saponins and their mechanisms of action.

Basic Information

Product Name	Polygalasaponin F
CAS No.	882664-74-6
Molecular Formula	C59H96O27
Molecular Weight	1237.4 g/mol
Synonyms	Tenufolin Saponin F; Polygalasaponin XXVIII; 3-O-β-D-Glucopyranosyl (1→3)-β-D-glucopyranosyl presenegenin 28-O-β-D-xylopyranosyl (1→4)-α-L-rhamnopyranosyl (1→2)-[β-D-xylopyranosyl (1→4)]-β-D-fucopyranosyl ester; Tenuifolisaponin F; Polygala Saponin F
EINECS	Contact for details

Quality Control

Our Polygalasaponin F is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of analytical and pharmacological applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.