Description

Dacetuzumab is a humanized monoclonal antibody designed to target the CD40 antigen, a key regulator in immune cell activation and signaling. This targeted therapeutic agent is of significant interest for its potential in modulating immune responses in various clinical contexts. It is primarily utilized in advanced research and development within the biopharmaceutical sector, focusing on oncology and autoimmune disease applications. Dacetuzumab CAS NO 880486-59-9 represents a critical reagent for scientists and manufacturers developing next-generation immunotherapies.

Application

• Biopharmaceutical R&D: A key reagent in the research and development of novel immunomodulatory therapies.
• Oncology Research: Investigated for its potential in cancer immunotherapy by targeting CD40 on antigen-presenting cells to stimulate anti-tumor immune responses.
• Autoimmune Disease Studies: Used in preclinical studies to understand and potentially modulate overactive immune pathways in conditions like lupus or rheumatoid arthritis.
• Immunology Mechanism Studies: Essential for basic and applied research into CD40-mediated signaling pathways and B-cell/T-cell interactions.
• Process Development & Scale-up: Serves as a reference standard or material for developing and optimizing large-scale biomanufacturing processes for biologic drugs.
• Cell-Based Assay Development: Used in the development and validation of functional assays to screen for drug candidates or evaluate biological activity.

Basic Information

Product Name	Dacetuzumab
CAS No.	880486-59-9
Molecular Formula	Contact for details
Molecular Weight	Approx. 145-150 kDa (Contact for details)
Synonyms	SGN-40; Anti-CD40 Monoclonal Antibody; Humanized Anti-CD40 Antibody; huS2C6; Monoclonal Antibody SGN-40; Immunoglobulin G1, anti-(human CD40 antigen) (human-mouse monoclonal SGN-40 γ1-chain), disulfide with human-mouse monoclonal SGN-40 κ-chain, dimer
EINECS	Contact for details

Quality Control

Our Dacetuzumab is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation, and potency/bioactivity testing in relevant cell-based assays. We adhere to high standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing specific results for each parameter is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under controlled, dry conditions to maintain stability. Refer to the specific COA or data sheet for detailed storage and handling instructions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE, reducing)	> 95%
Purity (SEC-HPLC)	> 98% Monomer
Protein Content (A280)	Contact for details
Endotoxin	< 1.0 EU/mg
Bioactivity (Cell-based assay)	Contact for details
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.